Endocrine Abstracts

A 16-year-old male, previously well, presented with 3 days history of non-specific body ache and headache. His blood pressure was 194/127mmHg, heart rate 115 beats/minute but had normal examination findings otherwise. His BP was high throughout his admission and his BMI was 20 kg/m2. Drug history was unremarkable. We noted he had transaminitis with predominantly elevated alkaline phosphatase (ALP). His ALP was 397U/l(40-105 U/l), Alanine transaminase (ALT) 124U/l(0-50 U/l), As...

Introduction: Familial dysalbuminemic hyperthyroxinemia (FDH) is characterized by artefactual hyperthyroxinemia caused by enhanced binding affinity of thyroxine to the mutant albumin. However little is known about how FDH affects the measurement of thyroid hormones, especially FT3, across many assay platforms.Methods: Forty-eight genetically confirmed FDH patients (R218H mutation) had FT4 and FT3 measured with 1-step (ADVIA CENTAUR®, Siem...